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ea0038oc2.1 | Translational pathophysiology and therapeutics | SFEBES2015

Dual 5-α reductase inhibition promotes hepatic lipid accumulation in man as a result of changes to lipid metabolism in adipose tissue and the liver

Hazlehurst Jonathan , Oprescu Andrei , Nikolaou Nikolaos , Guida Riccardo Di , Grinbergs Annabel , Davies Nigel , Flintham Robert , Armstrong Matthew , Taylor Angela , Hughes Beverly , Yu Jinglei , Hodson Leanne , Dunn Warwick , Tomlinson Jeremy

Background and aims: 5α reductase 1 and 2 (SRD5A1 (expressed in liver and adipose), SRD5A2 (expressed in liver) inactivate cortisol to 5α-dihydrocortisol in addition to their role in the generation of dihydrotestosterone and therefore regulate the tissue availability of cortisol. Dutasteride (dual SRD5A1 and SRD5A2 inhibitor) and Finasteride (selective SRD5A2 inhibitor) are commonly prescribed, but their potential metabolic effects have only recently been identified....

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Dual 5-α reductase inhibition promotes hepatic lipid accumulation in man as a result of changes to lipid metabolism in adipose tissue and the liver

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